NARCOTIC ANTAGONIST ACTIVITY OF THE 3-PHENYL-PIPERIDINES WITH N-ANTAGONISTIC SUBSTITUTION
نویسندگان
چکیده
منابع مشابه
Synthesis, pharmacological action, and receptor binding affinity of the enantiomeric 1-(1-phenyl-3-methylcyclohexyl)piperidines.
The cis and trans enantiomers of the 1-(1-methylcyclohexyl)piperidines were prepared from either 3(R)- or 3(S)-methylcyclohexanone through the Bruylents reaction or a modified azide route, respectively. Separation of the intermediate amines 5 and 6 was achieved through chromatography or selective crystallization of a fumarate salt. The cis isomer 2b had about one-third of the affinity of phency...
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15 صفحه اولN,N-Dimethyl-N′-[3-(trifluoromethyl)phenyl]urea
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1973
ISSN: 0021-5198
DOI: 10.1254/jjp.23.742